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2024 Trend Updates: What Really Works In SEO & Content MarketingSearch Engine Journal
21 slides•617.8K views
The future of SEO is trending toward a more human-first and user-centric approach, powered by AI intelligence and collaboration. Are you ready?
Watch as we explore which SEO trends to prioritize to achieve sustainable growth and deliver reliable results. We’ll dive into best practices to adapt your strategy around industry-wide disruptions like SGE, how to navigate the top challenges SEO professionals are facing, and proven tactics for prioritizing quality and building trust.
You’ll hear:
- The top SEO trends to prioritize in 2024 to achieve long-term success.
- Predictions for SGE’s impact, and how to adapt.
- What E-E-A-T really means, and how to implement it holistically (hint: it’s never been more important).
With Zack Kadish and Alex Carchietta, we’ll show you which SEO trends to ignore and which to focus on, along with the solution to overcoming rapid, significant and disruptive Google algorithm updates.
If you’re looking to cut through the noise of constant SEO and content trends to drive success, you won’t want to miss this webinar.
Storytelling For The Web: Integrate Storytelling in your Design ProcessChiara Aliotta
39 slides•499.5K views
In this slides I explain how I have used storytelling techniques to elevate websites and brands and create memorable user experiences. You can discover practical tips as I showcase the elements of good storytelling and its applied to some examples of diverse brands/projects..
This presentation by Thibault Schrepel, Associate Professor of Law at Vrije Universiteit Amsterdam University, was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
How to Leverage AI to Boost Employee Wellness - Lydia Di Francesco - SocialHR...SocialHRCamp
28 slides•153.2K views
Speaker: Lydia Di Francesco
In this workshop, participants will delve into the realm of AI and its profound potential to revolutionize employee wellness initiatives. From stress management to fostering work-life harmony, AI offers a myriad of innovative tools and strategies that can significantly enhance the wellbeing of employees in any organization. Attendees will learn how to effectively leverage AI technologies to cultivate a healthier, happier, and more productive workforce. Whether it's utilizing AI-powered chatbots for mental health support, implementing data analytics to identify internal, systemic risk factors, or deploying personalized wellness apps, this workshop will equip participants with actionable insights and best practices to harness the power of AI for boosting employee wellness. Join us and discover how AI can be a strategic partner towards a culture of wellbeing and resilience in the workplace.
2024 State of Marketing Report – by HubspotMarius Sescu
43 slides•118.7K views
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Let's Talk About It: Gynecologic Cancer (Calm Body, Calm Mind - Using Your Bo...RheannaRandazzo
14 slides•16 views
Stress manifests in our thinking, emotions, and bodies. Recognizing those signs and building skills to address stress takes attention and effort. Cultivating skills to use your body as a tool to help you find calm and regain a sense of control can help you navigate moments of heightened anxiety. Join us on Wednesday, March 12th, to learn strategies for quieting your body and, thereby, calming your mind. Let’s Talk About It.
TRAGEDIES IN PHASE 1 CLINICAL TRIAL Dr ankush goyalDr Ankush goyal
12 slides•258 views
Phase 1 Clinical Trials: An Overview
Phase 1 clinical trials are the first stage of testing a new drug or treatment in humans. These trials primarily assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the investigational drug. Conducted on a small group of healthy volunteers (typically 20–100) or, in certain cases, patients with the target disease, Phase 1 trials aim to determine:
1. Safety and Tolerability – Identifying potential side effects and the maximum tolerated dose.
2. Pharmacokinetics (PK) – Studying drug absorption, distribution, metabolism, and excretion (ADME).
3. Pharmacodynamics (PD) – Understanding the drug’s biological effects and mechanism of action.
4. Dose Escalation and Determination – Establishing the optimal dosage for further trials.
These trials are usually open-label (no placebo control) and can be conducted in different designs, such as single ascending dose (SAD), multiple ascending dose (MAD), and food effect studies. While most drugs fail in this phase due to safety concerns, successful candidates proceed to Phase 2 trials, where efficacy is further evaluated.
echinocandins case presentation.dr ANKUSH GOYAL GMC PATIALADr Ankush goyal
10 slides•151 views
Echinocandins: A Comprehensive Overview
Introduction
Echinocandins are a class of antifungal agents that have gained significant prominence in the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species. They are considered second-line or first-line treatment options in cases of azole-resistant fungal infections. This document provides an in-depth discussion of echinocandins, including their chemical structure, mechanism of action, pharmacokinetics, spectrum of activity, clinical applications, resistance mechanisms, adverse effects, and future perspectives.
Historical Background
Echinocandins were first discovered in the late 20th century when researchers were exploring natural antifungal compounds derived from fungi and other microorganisms. The first echinocandin, pneumocandin B0, was isolated from Glarea lozoyensis. Further modifications led to the development of caspofungin, micafungin, and anidulafungin, which are the three currently approved echinocandins for clinical use.
Chemical Structure
Echinocandins are cyclic lipopeptides composed of a large cyclic hexapeptide core linked to a long-chain fatty acid side group. This unique structure is crucial for their antifungal activity and their pharmacokinetic properties. The lipid tail enhances the compound's binding affinity to fungal cells, while the cyclic peptide core is responsible for inhibiting fungal cell wall synthesis.
Mechanism of Action
Echinocandins exert their antifungal effects by selectively inhibiting the enzyme (1→3)-β-D-glucan synthase, which is essential for the synthesis of β-glucan, a major component of the fungal cell wall. The inhibition of β-glucan synthesis results in cell wall weakening, osmotic instability, and ultimately fungal cell lysis. This mechanism makes echinocandins highly selective for fungi, as mammalian cells lack β-glucan.
Pharmacokinetics
Echinocandins are administered intravenously due to their poor oral bioavailability. The pharmacokinetic properties of caspofungin, micafungin, and anidulafungin vary slightly, but they share several common features:
Distribution: Echinocandins exhibit extensive tissue penetration, particularly in the liver, spleen, lungs, and kidneys. However, their penetration into the cerebrospinal fluid (CSF) is limited, making them less effective for central nervous system fungal infections.
Metabolism: Caspofungin undergoes hepatic metabolism through hydrolysis and N-acetylation, while micafungin is metabolized by the liver via arylsulfatase and catechol-O-methyltransferase. Anidulafungin undergoes spontaneous degradation in the plasma without significant hepatic metabolism.
Elimination: The elimination of echinocandins varies; caspofungin is excreted through both hepatic and renal routes, micafungin is eliminated hepatically, and anidulafungin is primarily excreted via fecal routes due to spontaneous degradation.
Half-life: Caspofungin has a half-life of approximately 9-
Transforming patient care, surgical outcomes, and clinical decision-making through applications like predictive analytics, personalized anesthesia plans, and robotic-assisted procedures, while also raising ethical considerations regarding patient autonomy, data privacy, and algorithm bias.
Drugs acting on Respiratory System: Expectorants and Antitussives.pptxSivaGanesh552177
7 slides•314 views
The topic "Expectorants and Antitussives" is covered under Unit I of the Pharmacology of drugs acting on the Respiratory System, which is included in the course of Pharmacology III with course code BP602
**HIV Treatment: A Comprehensive Overview**
## Introduction
Human Immunodeficiency Virus (HIV) is a major global health challenge that affects millions of people. While there is no cure for HIV, advancements in medical research have led to effective treatment options that allow individuals with HIV to lead healthy lives. The primary treatment for HIV is antiretroviral therapy (ART), which helps to control the virus and prevent its progression to Acquired Immunodeficiency Syndrome (AIDS). This document explores the various aspects of HIV treatment, including its history, types of medications, effectiveness, side effects, challenges, and future developments.
## History of HIV Treatment
The history of HIV treatment dates back to the 1980s when the first cases of AIDS were identified. Researchers quickly began searching for treatments to combat the virus. In 1987, the first antiretroviral drug, zidovudine (AZT), was approved. While it provided some benefits, AZT had significant toxicity and limited long-term efficacy. Over time, scientists developed new classes of antiretroviral drugs, leading to the combination therapy approach, which has dramatically improved patient outcomes.
## Antiretroviral Therapy (ART)
### How ART Works
ART consists of a combination of drugs that target different stages of the HIV lifecycle. These medications reduce the viral load (the amount of HIV in the blood) to undetectable levels, thereby preventing the virus from weakening the immune system. ART also reduces the risk of HIV transmission to others.
### Classes of Antiretroviral Drugs
There are several classes of antiretroviral drugs, each working in different ways to inhibit the replication of HIV:
1. **Nucleoside Reverse Transcriptase Inhibitors (NRTIs)** - These drugs block reverse transcriptase, an enzyme HIV uses to convert its RNA into DNA. Examples include zidovudine (AZT), lamivudine (3TC), and tenofovir (TDF).
2. **Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)** - NNRTIs bind directly to reverse transcriptase and inhibit its function. Examples include efavirenz and nevirapine.
3. **Protease Inhibitors (PIs)** - These drugs prevent HIV from maturing and becoming infectious by inhibiting the protease enzyme. Examples include lopinavir and atazanavir.
4. **Integrase Strand Transfer Inhibitors (INSTIs)** - These drugs prevent HIV from integrating its genetic material into human DNA. Examples include raltegravir and dolutegravir.
5. **Entry Inhibitors** - These drugs prevent HIV from entering human cells. Examples include maraviroc (CCR5 antagonist) and enfuvirtide (fusion inhibitor).
6. **Pharmacokinetic Enhancers** - These drugs improve the effectiveness of other antiretroviral medications by increasing their concentration in the bloodstream. An example is ritonavir.
## Effectiveness of HIV Treatment
### Viral Suppression
When taken consistently, ART can reduce the viral load to undetectable levels. Studies have shown that individuals with u
Understanding the Impact of Revalidation on UK Healthcare Professionals.pdfMedical Apprisal
4 slides•68 views
Revalidation UK is a vital process ensuring healthcare professionals maintain high standards, enhancing patient safety and public trust. This mandatory assessment promotes continuous professional development, requiring practitioners to demonstrate competence, adhere to ethical guidelines, and engage in reflective practice. Despite challenges like administrative burdens and balancing clinical duties, revalidation fosters lifelong learning and accountability. Employers and regulatory bodies play a key role in supporting professionals through training, mentorship, and streamlined appraisal processes. As technology advances, revalidation UK will evolve to simplify compliance and enhance accessibility. By embracing revalidation, healthcare professionals contribute to a safer, more effective healthcare system, reinforcing trust and excellence in patient care across the UK.
The title "Nasal Decongestants and Respiratory Stimulants" is covered under Unit I of the Pharmacology of drugs acting on the Respiratory System, which is included in the course of Pharmacology III with course code BP602.
Learning Objectives:
1. Discuss free water clearance
2. Differentiate between diabetes insipidus and SIADH
3. Describe the control of extracellular fluid osmolarity and sodium concentration in terms of the osmoreceptor-ADH system and thirst mechanism
4. Describe the roles of Angiotensin II, Aldosterone, and salt appetite mechanism in the control of extracellular fluid osmolarity and sodium concentration
Epilepsy and Its Management
Introduction
Epilepsy is a chronic neurological disorder characterized by recurrent, unprovoked seizures. It affects millions of people worldwide, cutting across all age groups and ethnicities. Seizures result from excessive and abnormal cortical nerve cell activity in the brain, leading to temporary changes in movement, sensation, behavior, or consciousness. This document provides a comprehensive overview of epilepsy, including its causes, classification, symptoms, diagnosis, and management strategies.
Causes of Epilepsy
Epilepsy can arise due to multiple factors, including genetic predisposition, brain injuries, infections, or developmental disorders. Some common causes include:
Genetic Factors: Certain types of epilepsy have a hereditary component, suggesting that genetic mutations may contribute to its development.
Brain Trauma: Head injuries from accidents or sports activities can lead to epilepsy.
Stroke and Vascular Diseases: Stroke, which reduces oxygen supply to the brain, is a leading cause of epilepsy in older adults.
Infections: Conditions such as meningitis, encephalitis, and neurocysticercosis can trigger epilepsy.
Developmental Disorders: Disorders such as autism and neurofibromatosis have been linked to epilepsy.
Tumors and Structural Abnormalities: Brain tumors and congenital malformations can also lead to epileptic seizures.
Classification of Epilepsy
The International League Against Epilepsy (ILAE) classifies epilepsy based on the nature of seizures and their origin in the brain:
Focal (Partial) Seizures: Originate in one part of the brain and can be simple (without loss of consciousness) or complex (with impaired consciousness).
Generalized Seizures: Involve both hemispheres of the brain and include types such as absence, tonic-clonic, myoclonic, and atonic seizures.
Unknown Onset Seizures: When the starting point of the seizure is unclear.
Epilepsy Syndromes: Specific syndromes such as Lennox-Gastaut syndrome, Dravet syndrome, and Juvenile Myoclonic Epilepsy have distinct features and management strategies.
Symptoms of Epilepsy
The clinical manifestations of epilepsy depend on the type of seizure and the brain region involved. Symptoms may include:
Temporary confusion or staring spells
Uncontrollable jerking movements (convulsions)
Loss of consciousness or awareness
Sensory disturbances such as tingling or hallucinations
Emotional changes, anxiety, or déjà vu
Diagnosis of Epilepsy
A thorough medical evaluation is necessary to diagnose epilepsy accurately. The diagnostic process includes:
Medical History and Physical Examination: A detailed history of seizure episodes, triggers, and associated conditions is crucial.
Electroencephalogram (EEG): Measures electrical activity in the brain and identifies abnormal patterns suggestive of epilepsy.
Neuroimaging (MRI, CT Scan): Detects structural abnormalities, tumors, or brain injuries.
Blood Tests: Helps rule out metabolic or i
Classification of Selective Alpha Agonists Based on Generation
Selective alpha agonists can be classified into first-generation, second-generation, and third-generation based on their pharmacological properties, receptor specificity, and clinical applications.
1. First-Generation Selective Alpha Agonists
(Non-subtype selective, older agents, higher side effects)
These drugs act on α1 or α2 receptors but with lower specificity and more systemic side effects.
Selective α1 Agonists (Vasoconstrictors, Hypotension Treatment)
Methoxamine – Used to treat hypotension.
Phenylephrine – Used as a nasal decongestant and to increase blood pressure.
Midodrine – Used for orthostatic hypotension.
Metaraminol – Used in hypotensive states and shock.
Selective α2 Agonists (Centrally Acting, Anti-Hypertensive Drugs)
Clonidine – Used for hypertension, ADHD, and withdrawal syndromes.
Methyldopa – Used for hypertension, especially in pregnancy.
Guanfacine – Used in hypertension and ADHD.
2. Second-Generation Selective Alpha Agonists
(More receptor selectivity, improved safety profile, fewer side effects)
Selective α1 Agonists (Longer Duration, Specific Targeting)
Amidephrine – Used in hypotension.
Selective α2 Agonists (Better CNS Penetration, Neurological Uses)
Brimonidine – Used in glaucoma (reduces intraocular pressure).
Apraclonidine – Used in short-term treatment of glaucoma.
Tizanidine – Used as a muscle relaxant in spasticity.
Lofexidine – Used in opioid withdrawal treatment.
3. Third-Generation Selective Alpha Agonists
(Highly selective, fewer side effects, newer therapeutic applications)
Selective α2 Agonists (High Selectivity, Novel Applications)
Dexmedetomidine – Used as a sedative in ICU and anesthesia.
Medetomidine – Used in veterinary anesthesia.
Fadolmidine – Investigated for pain relief with fewer cardiovascular effects.
Detomidine – Used in veterinary medicine for sedation
Classification of Selective Beta Agonists Based on Generation
Selective β-adrenergic agonists can be classified into three generations based on their receptor selectivity, duration of action, and therapeutic advancements.
1. First-Generation Selective Beta Agonists
(Non-specific, Short-acting, Higher Side Effects)
Early β-agonists with partial selectivity, often affecting both β1 and β2 receptors.
Shorter duration of action, leading to frequent dosing requirements.
Key Drugs:
Isoproterenol – A non-selective β1 and β2 agonist, used for bradycardia and heart block.
Dobutamine – A selective β1 agonist, used in acute heart failure and cardiogenic shock.
Ritodrine – A selective β2 agonist, previously used for delaying preterm labor.
2. Second-Generation Selective Beta Agonists
(More Selective, Longer Duration, Improved Safety)
These drugs show improved selectivity for either β1 or β2 receptors, reducing unwanted cardiac effects.
Longer-acting compared to first-generation.
Selective β1 Agonists (Primarily Cardiac Stimulants)
Denopamine – Used in heart failure treatment.
Prenalte
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
8 slides•51K views
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
21 slides•36.8K views
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
Let's Talk About It: Gynecologic Cancer (Calm Body, Calm Mind - Using Your Bo...RheannaRandazzo
14 slides•16 views
Stress manifests in our thinking, emotions, and bodies. Recognizing those signs and building skills to address stress takes attention and effort. Cultivating skills to use your body as a tool to help you find calm and regain a sense of control can help you navigate moments of heightened anxiety. Join us on Wednesday, March 12th, to learn strategies for quieting your body and, thereby, calming your mind. Let’s Talk About It.
TRAGEDIES IN PHASE 1 CLINICAL TRIAL Dr ankush goyalDr Ankush goyal
12 slides•258 views
Phase 1 Clinical Trials: An Overview
Phase 1 clinical trials are the first stage of testing a new drug or treatment in humans. These trials primarily assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the investigational drug. Conducted on a small group of healthy volunteers (typically 20–100) or, in certain cases, patients with the target disease, Phase 1 trials aim to determine:
1. Safety and Tolerability – Identifying potential side effects and the maximum tolerated dose.
2. Pharmacokinetics (PK) – Studying drug absorption, distribution, metabolism, and excretion (ADME).
3. Pharmacodynamics (PD) – Understanding the drug’s biological effects and mechanism of action.
4. Dose Escalation and Determination – Establishing the optimal dosage for further trials.
These trials are usually open-label (no placebo control) and can be conducted in different designs, such as single ascending dose (SAD), multiple ascending dose (MAD), and food effect studies. While most drugs fail in this phase due to safety concerns, successful candidates proceed to Phase 2 trials, where efficacy is further evaluated.
echinocandins case presentation.dr ANKUSH GOYAL GMC PATIALADr Ankush goyal
10 slides•151 views
Echinocandins: A Comprehensive Overview
Introduction
Echinocandins are a class of antifungal agents that have gained significant prominence in the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species. They are considered second-line or first-line treatment options in cases of azole-resistant fungal infections. This document provides an in-depth discussion of echinocandins, including their chemical structure, mechanism of action, pharmacokinetics, spectrum of activity, clinical applications, resistance mechanisms, adverse effects, and future perspectives.
Historical Background
Echinocandins were first discovered in the late 20th century when researchers were exploring natural antifungal compounds derived from fungi and other microorganisms. The first echinocandin, pneumocandin B0, was isolated from Glarea lozoyensis. Further modifications led to the development of caspofungin, micafungin, and anidulafungin, which are the three currently approved echinocandins for clinical use.
Chemical Structure
Echinocandins are cyclic lipopeptides composed of a large cyclic hexapeptide core linked to a long-chain fatty acid side group. This unique structure is crucial for their antifungal activity and their pharmacokinetic properties. The lipid tail enhances the compound's binding affinity to fungal cells, while the cyclic peptide core is responsible for inhibiting fungal cell wall synthesis.
Mechanism of Action
Echinocandins exert their antifungal effects by selectively inhibiting the enzyme (1→3)-β-D-glucan synthase, which is essential for the synthesis of β-glucan, a major component of the fungal cell wall. The inhibition of β-glucan synthesis results in cell wall weakening, osmotic instability, and ultimately fungal cell lysis. This mechanism makes echinocandins highly selective for fungi, as mammalian cells lack β-glucan.
Pharmacokinetics
Echinocandins are administered intravenously due to their poor oral bioavailability. The pharmacokinetic properties of caspofungin, micafungin, and anidulafungin vary slightly, but they share several common features:
Distribution: Echinocandins exhibit extensive tissue penetration, particularly in the liver, spleen, lungs, and kidneys. However, their penetration into the cerebrospinal fluid (CSF) is limited, making them less effective for central nervous system fungal infections.
Metabolism: Caspofungin undergoes hepatic metabolism through hydrolysis and N-acetylation, while micafungin is metabolized by the liver via arylsulfatase and catechol-O-methyltransferase. Anidulafungin undergoes spontaneous degradation in the plasma without significant hepatic metabolism.
Elimination: The elimination of echinocandins varies; caspofungin is excreted through both hepatic and renal routes, micafungin is eliminated hepatically, and anidulafungin is primarily excreted via fecal routes due to spontaneous degradation.
Half-life: Caspofungin has a half-life of approximately 9-
Transforming patient care, surgical outcomes, and clinical decision-making through applications like predictive analytics, personalized anesthesia plans, and robotic-assisted procedures, while also raising ethical considerations regarding patient autonomy, data privacy, and algorithm bias.
Drugs acting on Respiratory System: Expectorants and Antitussives.pptxSivaGanesh552177
7 slides•314 views
The topic "Expectorants and Antitussives" is covered under Unit I of the Pharmacology of drugs acting on the Respiratory System, which is included in the course of Pharmacology III with course code BP602
**HIV Treatment: A Comprehensive Overview**
## Introduction
Human Immunodeficiency Virus (HIV) is a major global health challenge that affects millions of people. While there is no cure for HIV, advancements in medical research have led to effective treatment options that allow individuals with HIV to lead healthy lives. The primary treatment for HIV is antiretroviral therapy (ART), which helps to control the virus and prevent its progression to Acquired Immunodeficiency Syndrome (AIDS). This document explores the various aspects of HIV treatment, including its history, types of medications, effectiveness, side effects, challenges, and future developments.
## History of HIV Treatment
The history of HIV treatment dates back to the 1980s when the first cases of AIDS were identified. Researchers quickly began searching for treatments to combat the virus. In 1987, the first antiretroviral drug, zidovudine (AZT), was approved. While it provided some benefits, AZT had significant toxicity and limited long-term efficacy. Over time, scientists developed new classes of antiretroviral drugs, leading to the combination therapy approach, which has dramatically improved patient outcomes.
## Antiretroviral Therapy (ART)
### How ART Works
ART consists of a combination of drugs that target different stages of the HIV lifecycle. These medications reduce the viral load (the amount of HIV in the blood) to undetectable levels, thereby preventing the virus from weakening the immune system. ART also reduces the risk of HIV transmission to others.
### Classes of Antiretroviral Drugs
There are several classes of antiretroviral drugs, each working in different ways to inhibit the replication of HIV:
1. **Nucleoside Reverse Transcriptase Inhibitors (NRTIs)** - These drugs block reverse transcriptase, an enzyme HIV uses to convert its RNA into DNA. Examples include zidovudine (AZT), lamivudine (3TC), and tenofovir (TDF).
2. **Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)** - NNRTIs bind directly to reverse transcriptase and inhibit its function. Examples include efavirenz and nevirapine.
3. **Protease Inhibitors (PIs)** - These drugs prevent HIV from maturing and becoming infectious by inhibiting the protease enzyme. Examples include lopinavir and atazanavir.
4. **Integrase Strand Transfer Inhibitors (INSTIs)** - These drugs prevent HIV from integrating its genetic material into human DNA. Examples include raltegravir and dolutegravir.
5. **Entry Inhibitors** - These drugs prevent HIV from entering human cells. Examples include maraviroc (CCR5 antagonist) and enfuvirtide (fusion inhibitor).
6. **Pharmacokinetic Enhancers** - These drugs improve the effectiveness of other antiretroviral medications by increasing their concentration in the bloodstream. An example is ritonavir.
## Effectiveness of HIV Treatment
### Viral Suppression
When taken consistently, ART can reduce the viral load to undetectable levels. Studies have shown that individuals with u
Understanding the Impact of Revalidation on UK Healthcare Professionals.pdfMedical Apprisal
4 slides•68 views
Revalidation UK is a vital process ensuring healthcare professionals maintain high standards, enhancing patient safety and public trust. This mandatory assessment promotes continuous professional development, requiring practitioners to demonstrate competence, adhere to ethical guidelines, and engage in reflective practice. Despite challenges like administrative burdens and balancing clinical duties, revalidation fosters lifelong learning and accountability. Employers and regulatory bodies play a key role in supporting professionals through training, mentorship, and streamlined appraisal processes. As technology advances, revalidation UK will evolve to simplify compliance and enhance accessibility. By embracing revalidation, healthcare professionals contribute to a safer, more effective healthcare system, reinforcing trust and excellence in patient care across the UK.
The title "Nasal Decongestants and Respiratory Stimulants" is covered under Unit I of the Pharmacology of drugs acting on the Respiratory System, which is included in the course of Pharmacology III with course code BP602.
Learning Objectives:
1. Discuss free water clearance
2. Differentiate between diabetes insipidus and SIADH
3. Describe the control of extracellular fluid osmolarity and sodium concentration in terms of the osmoreceptor-ADH system and thirst mechanism
4. Describe the roles of Angiotensin II, Aldosterone, and salt appetite mechanism in the control of extracellular fluid osmolarity and sodium concentration
Epilepsy and Its Management
Introduction
Epilepsy is a chronic neurological disorder characterized by recurrent, unprovoked seizures. It affects millions of people worldwide, cutting across all age groups and ethnicities. Seizures result from excessive and abnormal cortical nerve cell activity in the brain, leading to temporary changes in movement, sensation, behavior, or consciousness. This document provides a comprehensive overview of epilepsy, including its causes, classification, symptoms, diagnosis, and management strategies.
Causes of Epilepsy
Epilepsy can arise due to multiple factors, including genetic predisposition, brain injuries, infections, or developmental disorders. Some common causes include:
Genetic Factors: Certain types of epilepsy have a hereditary component, suggesting that genetic mutations may contribute to its development.
Brain Trauma: Head injuries from accidents or sports activities can lead to epilepsy.
Stroke and Vascular Diseases: Stroke, which reduces oxygen supply to the brain, is a leading cause of epilepsy in older adults.
Infections: Conditions such as meningitis, encephalitis, and neurocysticercosis can trigger epilepsy.
Developmental Disorders: Disorders such as autism and neurofibromatosis have been linked to epilepsy.
Tumors and Structural Abnormalities: Brain tumors and congenital malformations can also lead to epileptic seizures.
Classification of Epilepsy
The International League Against Epilepsy (ILAE) classifies epilepsy based on the nature of seizures and their origin in the brain:
Focal (Partial) Seizures: Originate in one part of the brain and can be simple (without loss of consciousness) or complex (with impaired consciousness).
Generalized Seizures: Involve both hemispheres of the brain and include types such as absence, tonic-clonic, myoclonic, and atonic seizures.
Unknown Onset Seizures: When the starting point of the seizure is unclear.
Epilepsy Syndromes: Specific syndromes such as Lennox-Gastaut syndrome, Dravet syndrome, and Juvenile Myoclonic Epilepsy have distinct features and management strategies.
Symptoms of Epilepsy
The clinical manifestations of epilepsy depend on the type of seizure and the brain region involved. Symptoms may include:
Temporary confusion or staring spells
Uncontrollable jerking movements (convulsions)
Loss of consciousness or awareness
Sensory disturbances such as tingling or hallucinations
Emotional changes, anxiety, or déjà vu
Diagnosis of Epilepsy
A thorough medical evaluation is necessary to diagnose epilepsy accurately. The diagnostic process includes:
Medical History and Physical Examination: A detailed history of seizure episodes, triggers, and associated conditions is crucial.
Electroencephalogram (EEG): Measures electrical activity in the brain and identifies abnormal patterns suggestive of epilepsy.
Neuroimaging (MRI, CT Scan): Detects structural abnormalities, tumors, or brain injuries.
Blood Tests: Helps rule out metabolic or i
Classification of Selective Alpha Agonists Based on Generation
Selective alpha agonists can be classified into first-generation, second-generation, and third-generation based on their pharmacological properties, receptor specificity, and clinical applications.
1. First-Generation Selective Alpha Agonists
(Non-subtype selective, older agents, higher side effects)
These drugs act on α1 or α2 receptors but with lower specificity and more systemic side effects.
Selective α1 Agonists (Vasoconstrictors, Hypotension Treatment)
Methoxamine – Used to treat hypotension.
Phenylephrine – Used as a nasal decongestant and to increase blood pressure.
Midodrine – Used for orthostatic hypotension.
Metaraminol – Used in hypotensive states and shock.
Selective α2 Agonists (Centrally Acting, Anti-Hypertensive Drugs)
Clonidine – Used for hypertension, ADHD, and withdrawal syndromes.
Methyldopa – Used for hypertension, especially in pregnancy.
Guanfacine – Used in hypertension and ADHD.
2. Second-Generation Selective Alpha Agonists
(More receptor selectivity, improved safety profile, fewer side effects)
Selective α1 Agonists (Longer Duration, Specific Targeting)
Amidephrine – Used in hypotension.
Selective α2 Agonists (Better CNS Penetration, Neurological Uses)
Brimonidine – Used in glaucoma (reduces intraocular pressure).
Apraclonidine – Used in short-term treatment of glaucoma.
Tizanidine – Used as a muscle relaxant in spasticity.
Lofexidine – Used in opioid withdrawal treatment.
3. Third-Generation Selective Alpha Agonists
(Highly selective, fewer side effects, newer therapeutic applications)
Selective α2 Agonists (High Selectivity, Novel Applications)
Dexmedetomidine – Used as a sedative in ICU and anesthesia.
Medetomidine – Used in veterinary anesthesia.
Fadolmidine – Investigated for pain relief with fewer cardiovascular effects.
Detomidine – Used in veterinary medicine for sedation
Classification of Selective Beta Agonists Based on Generation
Selective β-adrenergic agonists can be classified into three generations based on their receptor selectivity, duration of action, and therapeutic advancements.
1. First-Generation Selective Beta Agonists
(Non-specific, Short-acting, Higher Side Effects)
Early β-agonists with partial selectivity, often affecting both β1 and β2 receptors.
Shorter duration of action, leading to frequent dosing requirements.
Key Drugs:
Isoproterenol – A non-selective β1 and β2 agonist, used for bradycardia and heart block.
Dobutamine – A selective β1 agonist, used in acute heart failure and cardiogenic shock.
Ritodrine – A selective β2 agonist, previously used for delaying preterm labor.
2. Second-Generation Selective Beta Agonists
(More Selective, Longer Duration, Improved Safety)
These drugs show improved selectivity for either β1 or β2 receptors, reducing unwanted cardiac effects.
Longer-acting compared to first-generation.
Selective β1 Agonists (Primarily Cardiac Stimulants)
Denopamine – Used in heart failure treatment.
Prenalte
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
8 slides•51K views
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
21 slides•36.8K views
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
29 slides•67.5K views
Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
PEPSICO Presentation to CAGNY Conference Feb 2024Neil Kimberley
39 slides•35.4K views
PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.
Content Methodology: A Best Practices Report (Webinar)contently
50 slides•18.6K views
This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.
How to Prepare For a Successful Job Search for 2024Albert Qian
37 slides•40.7K views
The document provides guidance on preparing a job search for 2024. It discusses the state of the job market, focusing on growth in AI and healthcare but also continued layoffs. It recommends figuring out what you want to do by researching interests and skills, then conducting informational interviews. The job search should involve building a personal brand on LinkedIn, actively applying to jobs, tailoring resumes and interviews, maintaining job hunting as a habit, and continuing self-improvement. Once hired, the document advises setting new goals and keeping skills and networking active in case of future opportunities.
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
31 slides•20K views
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
16 slides•18.6K views
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
69 slides•67K views
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.
Google's Just Not That Into You: Understanding Core Updates & Search IntentLily Ray
99 slides•18.6K views
1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
42 slides•176.7K views
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
27 slides•41.5K views
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
138 slides•60K views
During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
• Learn how to use ChatGPT to add AI power to your testing and test automation
• Understand the limitations of the technology and where human expertise is crucial
• Gain insight into different AI-based tools
• Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.
12 Ways to Increase Your Influence at WorkGetSmarter
64 slides•405.9K views
Make your sensual moment special, until it becomes a memory
1. Make Your Sexual Moment Special, Until It Becomes a Memory
Male sexual dysfunction is the term causes the many ears to stand on listening to it. It includes
the most going through disorder one is Erectile Dysfunction and another one is Premature
Ejaculation. Both the disorder had disturbed the lifestyle of the many males as it hampers the
happiness that they want to have in their life. Erectile and the ejaculatory problems together
comprise to form the most rampant disorders among the men.
Understand Your Disarray
Erectile Dysfunction: This disorder has drag out the life of the many people as it
affected the living of the male along with his partner as well. This dysfunction makes the
males not able to have the erection in the natural way. This happens because they do not
receive the satisfactory amount of the blood towards the penis thus making it unable to
achieve the sufficient erection required for the sexual activity.
2. Premature Ejaculation: Premature Ejaculation is defined as the rapid or early
ejaculation which ranges in the age group of 18- 60 years. Premature Ejaculation is
normally exemplify by the involuntary control over the release or can say the ejaculation.
Most of the men due to the excitement ejaculate sooner in comparison with their partner
while involving in the love making. Due to this it frustrate many men as it decreases the
enjoyment, affect the relationship and also the superiority of the life.
Both the crisis has challenged the way the males are living. Both of these make the couple to
experience the difficulty in having the immense sexual relationship.
Looking For the Approach to Talk About This
The initial step in bringing back your relationship to the track is to finding the ways to converse
with each other addressing your problem.
3. We know that men feel ashamed while talking about this but you have to take a footstep towards
it. It is not simple to talk about this but you have to discuss it gradually by talking about it
honestly. You have to tell all what you feel so that your partner understands you. You have to
keep aside all your guilt, your fear or your nervousness and talk about it without giving a
thought.
Are Erectile Dysfunction And Premature Ejaculation Interlinked?
As Erectile Dysfunction is the primary diagnosed dysfunction among the male sexual disorder,
Premature Ejaculation has taken the second position among it. Many of the people confused it as
the same as both are the sexual dysfunction but if we seen it in the anatomical term then both are
the different thing.
As discussed above, in Erectile Dysfunction the penis does not get the proper amount of the
blood whereas in Premature Ejaculation the problem is linked with the Central Nervous System.
When the amount of the serotonin in the brain gets decreases then the condition like premature
ejaculation occurs.
4. Approach towards the Therapy
The pharmaceutical industry has discovered a new medicine that has dual working towards the
Erectile Dysfunction and Premature Ejaculation as well. The most effective medicine for both
the disorder is Super Avana or Super Avagra which has the twin drugs called Avanafil and
Dapoxetine. Two of them have the different way of functioning;
Avanafil: It works on the enzyme called phosphodiesterase type 5 by inhibiting it and enhancing
the amount of the cGMP which result in the relaxation of the smooth muscles and dilation of the
blood arteries that causes the sufficient supply of the blood towards it resulting in the natural
erection.
Dapoxetine: Dapoxetine works as a Selective Serotonin Reuptake Inhibitor (SSRI) that increases
the amount of the serotonin in the brain that slows down the ejaculation time thus increase the
chances of getting satisfied.
5. Some of the precautions are also linked with the medicine that makes the person to take the extra
precautions. It is always suggested to have the amount of the medicine in the prescribed amount
as if you take the medicine in the extra amount then the chances are there that it can result in the
overdosing.
The medicine is always store at the temperature that ranges in between 20 to 30 degrees. The
drug is never given to the patients who are already having the disease related with the heart, liver
and the kidney.
So, you can buy Super Avana and Super Avagra online from BuyMeds247Online to the
world most trusted pharmacy store at best price.